MicroRNA and Renal Allograft Monitoring

microrna and renal allograft monitoring

MicroRNA and Renal Allograft Monitoring

Implication for health policy/practice/research/medical education: Renal allograft monitoring is a great challenge of transplantation medicine and different biomarkers have been proposed. MicroRNA is an appealing biomarker because we could trace it from different sources including biopsy samples urine and blood, particularly, miRNA signature of stable and impending to failure allograft in urin...

MicroRNA expression profiles predictive of human renal allograft status.

Immune rejection of organ transplants is a life-threatening complication and is exemplified by alterations in the expression of protein-encoding genes. Because microRNAs (miRNAs) regulate the expression of genes implicated in adaptive immunity, we investigated whether acute rejection (AR) is associated with alterations in miRNA expression within allografts and whether expression profiles are di...

Noninvasive monitoring of mouse renal allograft rejection using micro-CT

PURPOSE Acute renal graft rejection can only be definitively diagnosed by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Micro-CT is widely used in preclinical studies of small animals. Here, we propose micro-CT could noninvasively monitor and evaluate renal location and function in a mouse kidney transplant model. METHODS Orthotopic kidney transplantation w...

Biological mechanism analysis of acute renal allograft rejection: integrated of mRNA and microRNA expression profiles.

OBJECTIVES Renal transplantation is the preferred method for most patients with end-stage renal disease, however, acute renal allograft rejection is still a major risk factor for recipients leading to renal injury. To improve the early diagnosis and treatment of acute rejection, study on the molecular mechanism of it is urgent. METHODS MicroRNA (miRNA) expression profile and mRNA expression p...